Clinical trials city of hope

Yanhong Shi and her team at City of Hope, a research and treatment center for cancer, have discovered a potential therapy that they have tested that has been shown to suppress GBM tumor growth and extend the lifespan of tumor-bearing mice.

Shi and her team first started by looking at PUS7, a gene that is highly expressed in GBM tissue in comparison to normal brain tissue.

Qi Cui, a scientist in Dr. The team then studied different glioblastoma stem cells GSCs , which play a vital role in brain tumor growth, and found that shutting off the PUS7 gene prevented GSC growth and self-renewal. The team then proceeded to look for an inhibitor of PUS7 from a database of thousands of different compounds and drugs approved by the Food and Drug Administration FDA.

After identifying a promising compound, the researchers tested the potential therapy in mice implanted with GSCs with the PUS7 gene. What they found was remarkable. The therapy inhibited the growth of brain tumors in the mice and their survival was significantly prolonged. The full study was published in Nature Cancer.

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Dow Futures 36, Nasdaq Futures 15, Today, through advances such as immunotherapy, precision medicine and other treatments available through clinical trials, there are better survival rates and fewer side effects than ever before," Stone said. Subscribe to our daily curated newsletter to receive the latest exclusive Reuters coverage delivered to your inbox. Create a job alert and receive personalized job recommendations straight to your inbox.

Skip to main content. This job has expired. Save job - Click to add the job to your shortlist. You need to sign in or create an account to save a job. Send job. Job Details Company Job Details About City of Hope City of Hope, an innovative biomedical research, treatment and educational institution with over 6, employees, is dedicated to the prevention and cure of cancer and other life-threatening diseases and guided by a compassionate, patient-centered philosophy.

City of Hope is a National Cancer Institute designated Comprehensive Cancer Center and a founding member of the National Comprehensive Cancer Network, an alliance of the nation's leading cancer centers that develops and institutes standards of care for cancer treatment. Position Summary Coordinates and develops coverage analyses and budgets for both industry sponsored and non-industry sponsored clinical trials, along with any corresponding amendments.

Liaises between external sponsors and COH departments to determine suitable coverage justifications and cost allocations for unique clinical trial procedures.